Effects of combined desogestrel-ethinylestradiol treatment on lipid profiles in women with polycystic ovarian disease.

A longitudinal study was conducted to determine the effect of combined desogestrel-ethinylestradiol treatment on lipid profiles in 28 women with polycystic ovarian disease. Mean patient age was 26.3 years (range, 16 to 36 years). Mean patient weight and height were 59.2 kg and 153.8 cm, respectively. After initial assessment, all patients were treated with a cyclical pill containing 150 micrograms desogestrel and 30 micrograms ethinylestradiol. Clinical, hormonal, and lipid determinations were evaluated after 3 and 6 cycles of treatment. The results revealed that, during the treatment course, serum luteinizing hormone, testosterone (T), free testosterone, and dehydroepiandrosterone sulfate decreased significantly, while serum follicle-stimulating hormone and prolactin levels did not change. Increased levels of total triglyceride, alpha, and prebeta lipoproteins, and decreased levels of beta lipoproteins, were observed. The ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol, although showing no significant change, had a tendency to decrease. This lipoprotein change seems to have a favorable rather than an adverse effect on the patients.
AuthorsA Rojanasakul, L Chailurkit, R Sirimongkolkasem, K Chaturachinda
JournalFertility and sterility (Fertil Steril) Vol. 48 Issue 4 Pg. 581-5 (Oct 1987) ISSN: 0015-0282 [Print] UNITED STATES
PMID2958365 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Lipoproteins
  • Norpregnenes
  • Triglycerides
  • Testosterone
  • Ethinyl Estradiol
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate
  • Desogestrel
  • Luteinizing Hormone
  • Adolescent
  • Adult
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Dehydroepiandrosterone (analogs & derivatives, blood)
  • Dehydroepiandrosterone Sulfate
  • Desogestrel
  • Drug Therapy, Combination
  • Ethinyl Estradiol (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Humans
  • Lipids (blood)
  • Lipoproteins (blood)
  • Luteinizing Hormone (blood)
  • Norpregnenes (administration & dosage, adverse effects, therapeutic use)
  • Polycystic Ovary Syndrome (blood, drug therapy)
  • Testosterone (blood)
  • Triglycerides (blood)

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