Chloroquine-induced cardiomyopathy.

Abstract

Biventricular hypertrophy and failure developed in two patients during treatment of systemic lupus erythematosus with chloroquine phosphate. In both patients, morphologic analysis of the myocardium, obtained by a right ventricular endomyocardial biopsy in one patient and at autopsy in the other, revealed accumulations of electron-dense concentric and parallel lamellae and curvilinear bodies within cardiac myocytes. These deposits were similar to those reported in chloroquine-induced skeletal myopathy and were considered to represent evidence of chloroquine-induced cardiotoxicity rather than a cardiovascular manifestation of the underlying disease. Clinical awareness and an endomyocardial biopsy specimen are necessary for the appropriate diagnosis of chloroquine-induced cardiomyopathy.

• Authors: H A McAllister Jr, V J Ferrans, R J Hall, N E Strickman, M I Bossart
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 111 Issue 10 Pg. 953-6 (Oct 1987) ISSN: 0003-9985 [Print] United States
• PMID: 2957973 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• chloroquine diphosphate
• Chloroquine

Topics

• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Cardiomegaly (chemically induced, pathology)
• Chloroquine (adverse effects, analogs & derivatives)
• Female
• Humans
• Lupus Erythematosus, Systemic (drug therapy)
• Microscopy, Electron
• Muscles (pathology)
• Myocardium (pathology)