Renal effects of synthetic rat-atrial natriuretic peptide in nephron-reduced rats with nephrotoxic nephritis.

Abstract

Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN.

• Authors: K Nitta, T Sanaka, H Kawaguchi, K Tsuchiya, M Sone, T Takuma, N Sugino
• Journal: The Japanese journal of experimental medicine (Jpn J Exp Med) Vol. 57 Issue 1 Pg. 41-5 (Feb 1987) ISSN: 0021-5031 [Print] Japan
• PMID: 2957529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immune Sera
• Atrial Natriuretic Factor

Topics

• Animals
• Atrial Natriuretic Factor (pharmacology)
• Blood Pressure (drug effects)
• Diuresis (drug effects)
• Glomerular Filtration Rate (drug effects)
• Immune Sera
• Kidney (drug effects, immunology, physiopathology)
• Male
• Natriuresis (drug effects)
• Nephrectomy
• Nephritis (immunology, physiopathology)
• Rats
• Rats, Inbred Strains