A comparison of single-dose spectinomycin with five days of trimethoprim-sulfamethoxazole for the treatment of chancroid.

Abstract

In a controlled trial 32 patients with ulcers culture-positive for Haemophilus ducreyi were treated with a single 2-g dose of spectinomycin, and 20 patients were treated with a five-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 160/800 mg) twice daily. Both regimens rapidly eradicated H. ducreyi from ulcers, with subsequent healing of ulcers and buboes. The cure rates 14 days after initiation of therapy were 94% for spectinomycin and 95% for TMP-SMZ. Patients with H. ducreyi-negative ulcers who were treated with the same regimens also healed and did not show a significantly different efficacy for either regimen. Thus we found that the one-day regimen of spectinomycin was as effective for the treatment of chancroid as was TMP-SMZ given for five days. Further studies on a larger number of patients are needed to confirm our findings.

• Authors: L Fransen, H Nsanze, Jo-Ndinya-Achola, L D'Costa, A R Ronald, P Piot
• Journal: Sexually transmitted diseases (Sex Transm Dis) 1987 Apr-Jun Vol. 14 Issue 2 Pg. 98-101 ISSN: 0148-5717 [Print] United States
• PMID: 2956702 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Drug Combinations
• Trimethoprim, Sulfamethoxazole Drug Combination
• Spectinomycin
• Trimethoprim
• Sulfamethoxazole

Topics

• Adult
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Chancroid (drug therapy)
• Drug Administration Schedule
• Drug Combinations (administration & dosage, therapeutic use)
• Humans
• Male
• Prospective Studies
• Spectinomycin (administration & dosage, therapeutic use)
• Sulfamethoxazole (administration & dosage, therapeutic use)
• Trimethoprim (administration & dosage, therapeutic use)
• Trimethoprim, Sulfamethoxazole Drug Combination