Abstract |
A controlled, randomized, double-blind trial was performed in 34 hospitalized patients with chronic leg ulcers: 37 ulcerous legs were treated with Elase solution or with saline (placebo) solution. Elase was statistically significantly better in effect on debridement (p less than 0.05) and on enhancing of granulation (p less than 0.05) than saline in patients with chronic venous stasis ulcers. In patients with complex ulcers no statistically significant difference between the two treatments was seen.
|
Authors | W Westerhof, F C Jansen, F S de Wit, R H Cormane |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 17
Issue 1
Pg. 32-9
(Jul 1987)
ISSN: 0190-9622 [Print] United States |
PMID | 2956297
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Drug Combinations
- Solutions
- deoxyribonuclease, plasmin drug combination
- Deoxyribonucleases
- Fibrinolysin
|
Topics |
- Aged
- Aged, 80 and over
- Chronic Disease
- Clinical Trials as Topic
- Debridement
- Deoxyribonucleases
(therapeutic use)
- Double-Blind Method
- Drug Combinations
(therapeutic use)
- Female
- Fibrinolysin
(therapeutic use)
- Humans
- Leg Ulcer
(drug therapy, surgery)
- Male
- Middle Aged
- Preoperative Care
- Random Allocation
- Skin Transplantation
- Solutions
|