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Contact allergy to 2,4'-dihydroxy-(hydroxymethyl)-diphenyl methanes. Sensitizers in a phenol-formaldehyde resin.

Abstract
A particular phenol-formaldehyde resin of the resol type (P-F-R-2) was shown to be a good marker for patients with contact allergy. Eleven patients with sensitivity to P-F-R-2 participated in the study in which chromatographically separated fractions of P-F-R-2 were patch tested. This procedure was repeated until a positive reaction to a single substance was noted. In this study 2 sensitizers are reported. Investigations by mass-spectrometry and nuclear magnetic resonance spectrometry identified the compounds to be 2,4'-dihydroxy-3,3'-di-(hydroxymethyl)-diphenyl methane (2,4'-H-3,3'-HPM) and 2,4'-dihydroxy-3',5'-di-(hydroxymethyl)-diphenyl methane (2,4'-H-3',5'-HPM). Six of 11 patients reacted to at least one of the compounds and simultaneous reactions were noted in 4 patients. By patch testing with serial dilutions of the two sensitizers positive reactions were noted down to 0.14 X 10(-3)% and 0.41 X 10(-3)% w/v for 2,4'-H3,3'-HPM and 2,4'-H-3',5'-HPM respectively.
AuthorsM Bruze, S Fregert, L Persson, E Zimerson
JournalDermatosen in Beruf und Umwelt. Occupation and environment (Derm Beruf Umwelt) 1987 Mar-Apr Vol. 35 Issue 2 Pg. 52-5 ISSN: 0343-2432 [Print] Germany
PMID2954805 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 2,4'-dihydroxy-3',5'-di-(hydroxymethyl)diphenyl methane
  • 2,4'-dihydroxy-3,3'-di-(hydroxymethyl)diphenyl methane
  • Benzhydryl Compounds
Topics
  • Benzhydryl Compounds (adverse effects)
  • Dermatitis, Contact (etiology)
  • Dermatitis, Occupational (chemically induced)
  • Hand Dermatoses (chemically induced)
  • Humans
  • Patch Tests
  • Structure-Activity Relationship

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