Abstract |
A particular phenol-formaldehyde resin of the resol type (P-F-R-2) was shown to be a good marker for patients with contact allergy. Eleven patients with sensitivity to P-F-R-2 participated in the study in which chromatographically separated fractions of P-F-R-2 were patch tested. This procedure was repeated until a positive reaction to a single substance was noted. In this study 2 sensitizers are reported. Investigations by mass-spectrometry and nuclear magnetic resonance spectrometry identified the compounds to be 2,4'-dihydroxy-3,3'-di-(hydroxymethyl)-diphenyl methane (2,4'-H-3,3'-HPM) and 2,4'-dihydroxy-3',5'-di-(hydroxymethyl)-diphenyl methane (2,4'-H-3',5'-HPM). Six of 11 patients reacted to at least one of the compounds and simultaneous reactions were noted in 4 patients. By patch testing with serial dilutions of the two sensitizers positive reactions were noted down to 0.14 X 10(-3)% and 0.41 X 10(-3)% w/v for 2,4'-H3,3'-HPM and 2,4'-H-3',5'-HPM respectively.
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Authors | M Bruze, S Fregert, L Persson, E Zimerson |
Journal | Dermatosen in Beruf und Umwelt. Occupation and environment
(Derm Beruf Umwelt)
1987 Mar-Apr
Vol. 35
Issue 2
Pg. 52-5
ISSN: 0343-2432 [Print] Germany |
PMID | 2954805
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2,4'-dihydroxy-3',5'-di-(hydroxymethyl)diphenyl methane
- 2,4'-dihydroxy-3,3'-di-(hydroxymethyl)diphenyl methane
- Benzhydryl Compounds
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Topics |
- Benzhydryl Compounds
(adverse effects)
- Dermatitis, Contact
(etiology)
- Dermatitis, Occupational
(chemically induced)
- Hand Dermatoses
(chemically induced)
- Humans
- Patch Tests
- Structure-Activity Relationship
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