Relation of EGFR Mutation Status to Metabolic Activity in Localized Lung Adenocarcinoma and Its Influence on the Use of FDG PET/CT Parameters in Prognosis.

Abstract

OBJECTIVE:

The purposes of this study were to assess the relation between epidermal growth factor receptor (EGFR) mutation status and FDG PET/CT findings and to evaluate the influence of this relation on the use of FDG PET/CT parameters to establish a prognosis in cases of localized lung adenocarcinoma.

MATERIALS AND METHODS:

Patients with stage I and II lung adenocarcinomas were retrospectively enrolled. At the initial FDG PET/CT examination, maximum and peak standardized uptake, tumor-to-background ratio, and volumetric parameters of metabolic tumor volume and total lesion glycolysis were measured.

RESULTS:

The values of all the metabolic and volumetric FDG PET/CT parameters were significantly lower in EGFR mutant than in EGFR wild-type lung adenocarcinomas. All parameters were statistically significant for predicting recurrence-free survival. In multivariate analyses, peak standardized uptake and total lesion glycolysis were more significant prognostic factors than was TNM stage (p < 0.001). Optimal cutoff values of parameters for predicting recurrence-free survival were slightly different between the two groups.

CONCLUSION:

EGFR mutation is related to low metabolic activity of localized lung adenocarcinoma at FDG PET/CT. Because of differences in the metabolic activity of EGFR mutant and wild-type tumors, EGFR mutation status must be considered when FDG PET/CT parameters are used for prognosis.

• Authors: Yong-Il Kim, Jin Chul Paeng, Young Sik Park, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 210 Issue 6 Pg. 1346-1351 (Jun 2018) ISSN: 1546-3141 [Electronic] United States
• PMID: 29547059 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• EGFR protein, human
• ErbB Receptors

Topics

• Adenocarcinoma of Lung (diagnostic imaging, genetics, metabolism, pathology)
• Aged
• ErbB Receptors (genetics)
• Female
• Fluorodeoxyglucose F18
• Humans
• Male
• Middle Aged
• Mutation
• Neoplasm Staging
• Positron Emission Tomography Computed Tomography
• Prognosis
• Radiopharmaceuticals