Pain during angiography: a randomized double-blind trial comparing ioxaglate and diatrizoate.

Abstract

We performed a randomized, double-blind prospective study comparing pain experienced during peripheral and aortic angiography with two different contrast agents. Sixty patients, receiving a total of 107 injections, were randomized to receive either ioxaglate (Hexabrix) or sodium-meglumine diatrizoate (Renografin-76). Subjects scored the pain they experienced on a 10-point visual analog scale, and the physician also scored their discomfort on a five point scale. Hemodynamic parameters were monitored during the procedure in all patients, and subsequent hematology, serum chemistry, and urinalysis were performed in 19 of the 60 patients. There was a significant reduction in the degree of pain experienced by the Ioxaglate group compared to the reference group (p less than 0.001). The patients in the Hexabrix group had a mean pain score of 1.3 compared to the patients in the Renografin-76 group who had a mean pain score of 6.1. The two groups did not differ in their hemodynamic responses to the contrast agents, and no significant differences were noted in the subsequent laboratory measures.

• Authors: M Pathria, S Somers, G Gill
• Journal: Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes (Can Assoc Radiol J) Vol. 38 Issue 1 Pg. 32-4 (Mar 1987) ISSN: 0846-5371 [Print] United States
• PMID: 2953734 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Diatrizoate
• Diatrizoate Meglumine
• urovision
• Ioxaglic Acid

Topics

• Adult
• Aged
• Angiography (adverse effects)
• Clinical Trials as Topic
• Diatrizoate (adverse effects)
• Diatrizoate Meglumine (adverse effects)
• Double-Blind Method
• Drug Combinations (adverse effects)
• Hemodynamics (drug effects)
• Humans
• Ioxaglic Acid (adverse effects)
• Middle Aged
• Pain (chemically induced)
• Random Allocation