Beta-endorphin-(1-27) antagonizes beta-endorphin-induced hypothermia in mice.

Abstract

The effects of beta-endorphin and beta-endorphin-(1-27) on the body temperature of mice was studied at an ambient temperature of 10 degrees C. Intracerebroventricular injection of beta-endorphin (0.25-4 micrograms) and beta-endorphin-(1-27) (0.61 to 10 micrograms) caused a dose-related hypothermia. The duration of hypothermia induced by beta-endorphin-(1-27) was shorter than that induced by beta-endorphin. The hypothermia induced by 2 micrograms of beta-endorphin was attenuated by 5 micrograms of beta-endorphin-(1-27). Our results indicated that beta-endorphin-(1-27) is a partial agonist which produces a small degree of hypothermia and an antagonist which blocks the beta-endorphin-induced hypothermia.

• Authors: H H Suh, L F Tseng, C H Li
• Journal: Peptides (Peptides) 1987 Jan-Feb Vol. 8 Issue 1 Pg. 123-6 ISSN: 0196-9781 [Print] United States
• PMID: 2952945 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Endorphins
• Peptide Fragments
• beta-Endorphin
• beta-endorphin (1-27)

Topics

• Animals
• Body Temperature (drug effects)
• Endorphins (antagonists & inhibitors, pharmacology)
• Male
• Mice
• Peptide Fragments (pharmacology)
• Time Factors
• beta-Endorphin