[Effectiveness of piperacillin in the antibacterial treatment of intra-abdominal infections in children].

Abstract

The effectiveness of piperacillin was investigated in 30 children operated upon for peritonitis: 13 had acute appendicitis with puriform peritoneal reaction, or a recently perforated appendix; 5 had generalized peritonitis of appendicular origin, and 13 had intraperitoneal abscess. In the 12 children who underwent right iliac appendicectomy (with post-operative drainage in 3), piperacillin was administered alone during 5 days; clinical and bacteriological cure was obtained in all cases; the mean duration of stay in hospital was 7 days. The 5 cases of generalized peritonitis required drainage; piperacillin was given alone in 4 of them and combined with an aminoglycoside and metronidazole in one who was in poor general condition. Bacteriology showed a predominance of Escherichia coli alone or associated with other organisms. Clinical and bacteriological cure was obtained in 3 patients; the mean duration of stay in hospital was 12 days. Seven of the 13 cases of intraperitoneal abscess needed drainage. Piperacillin was administered alone for 7 days on average in 10 cases and combined with an aminoglycoside and metronidazole in 2 cases. Eight patients had a favourable course, 5 developed complications. In all 3 groups piperacillin was tell tolerated. A patch of urticaria was noted in 2 cases and a transient skin rash in 2 other cases. No neutropenia was observed in these children whose treatment never exceeded 10 days.

• Authors: M Vergnaud, P Ravasse, N Eustratiades, B Malbruny, M C Laschon, J Laurent, C Morel
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 15 Issue 46 Pg. 2342-4 (Dec 20 1986) ISSN: 0755-4982 [Print] France
• Vernacular Title: Efficacité de la pipéracilline dans le traitement antibactérien des infections intra-abdominales de l'enfant.
• PMID: 2949282 (Publication Type: English Abstract, Journal Article)

Chemical References

• Piperacillin

Topics

• Abscess (drug therapy, surgery)
• Adolescent
• Appendicitis (drug therapy, surgery)
• Child
• Child, Preschool
• Combined Modality Therapy
• Female
• Humans
• Male
• Peritoneal Diseases (drug therapy)
• Peritonitis (drug therapy, surgery)
• Piperacillin (therapeutic use)