A casein hydrolysate increases GLP-1 secretion and reduces food intake.

Abstract

In an effort to control weight gain, much attention has focused on the identification of bioactive peptides from food sources that induce satiety hormone secretion and increase the feeling of fullness. In this study, a screening platform identified a sodium caseinate hydrolysate, LFC25, that significantly increased calcium signalling in the enteroendocrine cell line, STC-1, and as a result increased secretion of the satiety hormone, GLP-1, in a dose-dependent manner. Administration of this hydrolysate to mice reduced the cumulative food intake over an eight hour period. To determine the feasibility of LFC25 as a food ingredient, production was scaled up to 10 L and spray-dried or freeze-dried without loss of bioactivity.

• Authors: Fiona O'Halloran, Christine Bruen, Brian McGrath, Harriët Schellekens, Brian Murray, John F Cryan, Alan L Kelly, Paul L H McSweeney, Linda Giblin
• Journal: Food chemistry (Food Chem) Vol. 252 Pg. 303-310 (Jun 30 2018) ISSN: 1873-7072 [Electronic] England
• PMID: 29478546 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Caseins
• casein hydrolysate
• Glucagon-Like Peptide 1

Topics

• Animals
• Caseins (chemistry, pharmacology)
• Cell Line
• Eating (drug effects)
• Enteroendocrine Cells (drug effects, metabolism)
• Glucagon-Like Peptide 1 (genetics, metabolism)
• Male
• Mass Spectrometry
• Mice
• Mice, Inbred C57BL