HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Selected pulmonary biochemical and hematological changes produced by prolonged hypoxia in the rat.

Abstract
Rats were exposed to 12% O2 (1 atm) for 48 hr, then 10% O2 for the duration of the exposures. Significant elevations in enzymes of the glutathione peroxidase system were found in the lungs of rats killed 3.5, 7.5, and 12.5 days of exposure compared to air-breathing controls. Superoxide dismutase was also elevated after hypoxia but nonsignificantly. Animals killed 12.5 days after exposures exhibited 75% (P less than 0.05) more thiobarbituric acid reactive products in their lungs compared to controls. These results along with significant increases of lung lipid peroxidation and in an augmentation of protective antiperoxidative lung defense capabilities. Hypoxia also resulted in enzyme elevations of lung phosphofructokinase and pyruvate kinase, which may indicate an adaptive increase in lung glycolytic capabilities which would be helpful in maintaining lung tissue energy requirements during hypoxia. In addition, it was confirmed that red blood cell count, hemoglobin and hematocrit values increased after prolonged hypoxia. The results of this study might also reflect enzyme elevation/induction due to cellular reparative-proliferative processes following hypoxia.
AuthorsA K Reddy, R E Kimball, S T Omaye
JournalExperimental and molecular pathology (Exp Mol Pathol) Vol. 45 Issue 3 Pg. 336-42 (Dec 1986) ISSN: 0014-4800 [Print] UNITED STATES
PMID2947810 (Publication Type: Journal Article)
Chemical References
  • Hemoglobins
  • Lipid Peroxides
  • Phosphogluconate Dehydrogenase
  • Glucosephosphate Dehydrogenase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Phosphofructokinase-1
  • Pyruvate Kinase
Topics
  • Animals
  • Anoxia (blood, enzymology, metabolism)
  • Erythrocyte Count
  • Glucosephosphate Dehydrogenase (metabolism)
  • Glutathione Peroxidase (metabolism)
  • Hematocrit
  • Hemoglobins (analysis)
  • Lipid Peroxides (metabolism)
  • Lung (enzymology, metabolism)
  • Male
  • Phosphofructokinase-1 (metabolism)
  • Phosphogluconate Dehydrogenase (metabolism)
  • Pyruvate Kinase (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Superoxide Dismutase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: