Phorbol ester receptors in cardiac myocytes of salt-sensitive and salt-resistant Dahl rats.

Abstract

A moderate degree of cardiac hypertrophy develops in salt-sensitive Dahl (DS) rats after 5 weeks on a high-salt (8% NaCl) diet. Cardiac hypertrophy is accompanied by a significant reduction in the number of phorbol ester receptors on enzymatically dissociated myocytes with no changes in their affinities. In contrast, the number and properties of these receptors are not influenced by variations of dietary salt intake in the salt-resistant Dahl (DR) rat. Since phorbol esters are closely related to protein kinase C, a potent stimulator of Ca2+ transport in the heart, these results suggest that loss of phorbol ester binding sites may limit the inotropic reserve of the hypertrophied myocardium.

• Authors: C J Limas, C Limas
• Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 4 Issue 3 Pg. S145-7 (Oct 1986) ISSN: 0952-1178 [Print] England
• PMID: 2946824 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Caenorhabditis elegans Proteins
• Carrier Proteins
• Phorbol Esters
• Receptors, Drug
• Receptors, Immunologic
• phorbol ester binding protein
• phorbol ester receptor
• Sodium Chloride
• Protein Kinase C

Topics

• Animals
• Caenorhabditis elegans Proteins
• Cardiomegaly (etiology, metabolism)
• Carrier Proteins
• Diet
• Hypertension (genetics, metabolism)
• Male
• Myocardium (metabolism)
• Phorbol Esters (metabolism)
• Protein Kinase C (metabolism)
• Rats
• Rats, Inbred Strains (metabolism)
• Receptors, Drug
• Receptors, Immunologic (metabolism)
• Sodium Chloride (administration & dosage, pharmacology)