Abstract |
Unilateral lesions of the nigro-striatal dopamine (DA) pathway induced contralateral rotations to apomorphine, increased (3H)-spiroperidol binding and enhanced the sensitivity of striatal adenylate cyclase to DA stimulation. Prolonged L-dopa administration counteracted the increased density of (3H)-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to DA and decreased the inhibitory effect of opiates on this enzyme. The apomorphine-induced contralateral rotations were also strongly potentiated. On the contrary the binding of (3H)-SCH-23390 was affected neither by DA nerve degeneration nor by chronic L-dopa treatment. These results suggest that DA-D1 and DA-D2 receptors are differently affected by prolonged L-dopa treatment. The biochemical changes of DA-D1 receptors associated with adenylate cyclase seem to be correlated with the enhanced behavioural responses to apomorphine and could be a consequence of a decreased opiate inhibitory tone on the enzyme. The increased supersensitivity of the DA-D1 receptors may play a role in the clinical changes seen in parkinsonian patients following chronic use of L-dopa.
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Authors | A Groppetti, C Flauto, E Parati, A Vescovi, L Rusconi, M Parenti |
Journal | Journal of neural transmission. Supplementum
(J Neural Transm Suppl)
Vol. 22
Pg. 33-45
( 1986)
ISSN: 0303-6995 [Print] Austria |
PMID | 2946813
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzazepines
- Hydroxydopamines
- Receptors, Dopamine
- Receptors, Dopamine D1
- Levodopa
- Spiperone
- Sulpiride
- Oxidopamine
- Adenylyl Cyclases
- Carbidopa
- Apomorphine
- Dopamine
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Topics |
- Adenylyl Cyclases
(metabolism)
- Animals
- Apomorphine
(pharmacology)
- Benzazepines
(metabolism, pharmacology)
- Carbidopa
(pharmacology)
- Corpus Striatum
(drug effects)
- Dopamine
(physiology)
- Hydroxydopamines
(pharmacology)
- Levodopa
(pharmacology)
- Male
- Oxidopamine
- Rats
- Rats, Inbred Strains
- Receptors, Dopamine
(drug effects)
- Receptors, Dopamine D1
- Spiperone
(metabolism)
- Stereotyped Behavior
(drug effects)
- Substantia Nigra
(physiology)
- Sulpiride
(pharmacology)
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