Abstract |
Difficulty in distinguishing between monosymptomatic optic neuritis due to autoimmune disease or to intrinsic demyelination in young adults prompted a trial administration of megadose corticosteroids in a series of patients. Treatment with 1 g daily of intravenous methylprednisolone ( Solu-Medrol) for 2 to 5 days led to the rapid resolution and restoration of visual function in five patients. Two untreated patients suffered irreversible loss of vision. One patient with known autoimmune disease required a higher dose. The author suggests a trial of megadose, intravenous corticosteroids in patients between the ages of 21 and 45 years with optic neuropathies of uncertain or suspected autoimmune etiology after appropriate neuro-ophthalmologic evaluation.
|
Authors | T C Spoor |
Journal | Journal of clinical neuro-ophthalmology
(J Clin Neuroophthalmol)
Vol. 6
Issue 3
Pg. 137-43
(Sep 1986)
ISSN: 0272-846X [Print] United States |
PMID | 2946719
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Adrenal Cortex Hormones
- Prednisolone
|
Topics |
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Adult
- Dose-Response Relationship, Drug
- Female
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Optic Neuritis
(drug therapy, physiopathology)
- Prednisolone
(therapeutic use)
|