HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3.

Abstract
The linked DNA marker for Huntington disease has recently been mapped to the short arm of chromosome 4 by somatic cell hybridization studies. Southern blot analysis of DNA from patients with Wolf-Hirschhorn syndrome (WHS) has suggested that the linked marker maps within the terminal 4p16 band. We have now accomplished subregional assignment of G8 (D4S10) to 4p16.1-16.3 using in situ hybridization techniques on two patients with nonoverlapping interstitial deletions of 4p. The mapping of G8 (D4S10) to a region deleted in patients with WHS will allow the application of new strategies for detecting DNA sequences closer to the locus for Huntington disease.
AuthorsH S Wang, C R Greenberg, J Hewitt, D Kalousek, M R Hayden
JournalAmerican journal of human genetics (Am J Hum Genet) Vol. 39 Issue 3 Pg. 392-6 (Sep 1986) ISSN: 0002-9297 [Print] United States
PMID2945429 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Genetic Markers
Topics
  • Chromosome Banding
  • Chromosome Deletion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Huntington Disease (genetics)
  • Karyotyping
  • Nucleic Acid Hybridization

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: