Abstract |
The linked DNA marker for Huntington disease has recently been mapped to the short arm of chromosome 4 by somatic cell hybridization studies. Southern blot analysis of DNA from patients with Wolf-Hirschhorn syndrome (WHS) has suggested that the linked marker maps within the terminal 4p16 band. We have now accomplished subregional assignment of G8 (D4S10) to 4p16.1-16.3 using in situ hybridization techniques on two patients with nonoverlapping interstitial deletions of 4p. The mapping of G8 (D4S10) to a region deleted in patients with WHS will allow the application of new strategies for detecting DNA sequences closer to the locus for Huntington disease.
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Authors | H S Wang, C R Greenberg, J Hewitt, D Kalousek, M R Hayden |
Journal | American journal of human genetics
(Am J Hum Genet)
Vol. 39
Issue 3
Pg. 392-6
(Sep 1986)
ISSN: 0002-9297 [Print] United States |
PMID | 2945429
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Chromosome Banding
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Genetic Linkage
- Genetic Markers
- Humans
- Huntington Disease
(genetics)
- Karyotyping
- Nucleic Acid Hybridization
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