MicroRNAs (
miRNAs) play crucial roles in the progression of different
tumors. In our study, we investigated the expression and roles of miR-411 in human
osteosarcoma. In this study, we first confirmed that the miR-411 expression was higher in the serum of patients with
osteosarcoma than in the serum of healthy volunteers. In addition, we found that the miR-411 expression was upregulated in the
osteosarcoma tissues compared to that in the matched normal bone tissues. We also demonstrated that the miR-411 expression was upregulated in the four
osteosarcoma cell lines. Elevated expression of miR-411 promoted
osteosarcoma cell proliferation and migration. Moreover, we identified that
metastasis suppressor protein 1 (MTSS1) was a direct target gene of miR-411 in the
osteosarcoma cell. We also demonstrated that the MTSS1 expression was downregulated in the
osteosarcoma tissues compared to that in the matched normal bone tissues. In addition, MTSS1 expression level was inversely correlated with miR-411 expression in the
osteosarcoma tissues. Furthermore, elevated expression of miR-411 enhanced the
osteosarcoma cell proliferation and migration through inhibiting the MTSS1 expression. These data suggested that miR-411 played as oncogene in the
osteosarcoma partly by inhibiting the MTSS1 expression.