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Laminin M is found in placental basement membranes, but not in basement membranes of neoplastic origin.

Abstract
Laminin is a high molecular weight glycoprotein found in all basement membranes studied to date. Two subunits of laminin, A and B, have been isolated and characterized from a variety of tumor matrices. Recently we have reported the finding, in human placenta, of a new laminin subunit which we termed M. In the present study we report on the presence of laminin M in placentae of other species such as bovine, rat and mouse. In addition, we have examined laminin extracted from mouse EHS-tumor, rat ED-PYS carcinoma and three human carcinoma cell lines. The laminin subunits were detected by the electroimmunoblot technique using antibodies against mouse, rat and human laminin. Laminin M could not be demonstrated either in the two murine tumors, or in the three different human neoplastic cell lines studied. If the absence of laminin M is the consequence of neoplastic transformation, then studies of the metabolism of this subunit may provide new information on neoplastic transformation and invasion, and a useful marker in tumor diagnosis.
AuthorsM Ohno, A Martinez-Hernandez, N Ohno, N A Kefalides
JournalConnective tissue research (Connect Tissue Res) Vol. 15 Issue 3 Pg. 199-207 ( 1986) ISSN: 0300-8207 [Print] England
PMID2944712 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Laminin
Topics
  • Animals
  • Basement Membrane (analysis)
  • Cattle
  • Cell Line
  • Female
  • Humans
  • Laminin (analysis)
  • Mice
  • Molecular Weight
  • Neoplasms (analysis)
  • Neoplasms, Experimental (analysis)
  • Placenta (analysis)
  • Pregnancy
  • Rats
  • Species Specificity

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