Comparative efficacy of ciprofloxacin and ceftriaxone in experimental arthritis caused by Escherichia coli.

Abstract

Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. Both agents significantly reduced mean E. coli counts in septic joint fluid (P less than 0.0005 versus untreated controls) and also within infected synovial tissue (P less than 0.01 versus controls). Ciprofloxacin regimens caused a higher frequency (P less than 0.05) of synovial tissue sterilization (53%) than did ceftriaxone (25%).

• Authors: A S Bayer, D C Norman, I K Blomquist
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 30 Issue 1 Pg. 184-6 (Jul 1986) ISSN: 0066-4804 [Print] United States
• PMID: 2944479 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Quinolines
• Ciprofloxacin
• Ceftriaxone

Topics

• Animals
• Arthritis, Infectious (drug therapy, etiology)
• Ceftriaxone (metabolism, pharmacology)
• Ciprofloxacin
• Escherichia coli Infections (drug therapy)
• Female
• Quinolines (metabolism, pharmacology)
• Rabbits
• Synovial Fluid (metabolism)