Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial.

Abstract

BACKGROUND:

Dental plaque is one of the predominant causes of major oral diseases. Although mechanical and chemical methods are extensively followed to control the development of plaque, plaque-related diseases still persist. Therefore, this necessitates for alternative measures of plaque control, one such alternative is photodynamic antimicrobial chemotherapy (PACT).

MATERIALS AND METHODS:

Split mouth randomized clinical trial (CTRI/2017/03/008239) was conducted on 30 participants who reported to the hospital. Participants were asked to rinse their mouth for 1 min using 10 ml of 25 μM erythrosine solutions. Same tooth on both quadrants of the same jaw are selected as the test and control. Intervention used was halogen-based composite curing light with wavelength of 500-590 nm. Plaque sample from the control tooth and test tooth was collected before and after exposure, respectively, and sent to microbiological laboratory for colony count.

RESULTS:

Logarithmic mean and standard deviation of control group with 102 dilutions of aerobic microbial count were found to be 5.34 ± 0.94, and for experimental group, it was 4.47 ± 1.37. The statistical difference between mean CFU values between aerobic bacterial counts was significant (P = 0.006).

CONCLUSIONS:

Erythrosine-mediated PACT reduces the extent of dental plaque microbial count and has a potential preventive and therapeutic use in day-to-day life and dental clinics.

• Authors: Manohar Bhat, Swathi Acharya, Kakarla Veera Venkata Prasad, Raghavendra Kulkarni, Anithraj Bhat, Devikripa Bhat
• Journal: Journal of Indian Society of Periodontology (J Indian Soc Periodontol) 2017 May-Jun Vol. 21 Issue 3 Pg. 210-215 ISSN: 0972-124X [Print] India
• PMID: 29440788 (Publication Type: Journal Article)