GnRH analogs inhibit the secretion of
gonadotropins and, therefore, that of
estrogens and
androgens of ovarian origin. The purpose of this study was to investigate the use of one superactive agonistic
GnRH analog,
nafarelin, in the treatment of
hirsutism. Six hirsute women were treated with
nafarelin (1 000 micrograms/day) for 6 months. An acute rise in serum
gonadotropin levels occurred in response to
nafarelin administration initially, but it lasted less than 2 weeks. Serum
gonadotropin,
testosterone, free
testosterone, and
androstenedione concentrations decreased significantly during treatment. Mean serum LH levels decreased from 17.9 +/- 4.6 (+/- SE) to 5.0 +/- 0.5 mIU/ml (P less than 0.01), and FSH decreased from 9.3 +/- 0.7 to 7.2 +/- 0.9 mIU/ml (P less than 0.05) after 1 month of treatment. The total
testosterone concentration fell from 0.77 +/- 0.10 to 0.40 +/- 0.14 ng/ml (P less than 0.01) after 1 month of
therapy, and free
testosterone decreased from 10.7 +/- 2.7 to 4.1 +/- 1.6 pg/ml (P less than 0.01) after 3 months.
Androstenedione levels decreased from 2.4 +/- 0.4 to 1.2 +/- 0.2 ng/ml (P less than 0.01) after 1 month of treatment. The mean concentrations of all of the above
hormones remained suppressed throughout treatment. Serum
5 alpha-androstane-3 alpha,17 beta-diol glucuronide levels did not decrease significantly during treatment, nor did
dehydroepiandrosterone sulfate levels. The mean
estradiol concentration during treatment was 34.8 +/- 3.1 pg/ml. The clinical response was very good; hair growth was slower, and new hair was less coarse compared to the pretreatment period.
Hirsutism scores (determined by Ferriman-Gallwey assessment of extent and quality of body hair) improved in four of the six patients. In the six patients, the mean score decreased significantly from 19.3 +/- 3.3 to 13.2 +/- 2.8 (P less than 0.05) at the end of treatment. These data demonstrate that by suppressing ovarian
androgen production,
nafarelin may be useful for the treatment of
hirsutism associated with either increased ovarian
androgen production or increased sensitivity of the hair follicle to normal concentrations of circulating
androgens.