Abstract | BACKGROUND: OBJECTIVES: METHODS: A double-blind randomized controlled study was performed. A total of 72 patients with SS were assigned randomly to receive 10 drops of pilocarpine (5 mg) or 10 drops of artificial saliva orally, three times daily for 12 weeks. Whole saliva and tear flow were evaluated at baseline and periodically throughout the study to provide a global assessment of dryness and to report any adverse effects. RESULTS: Patients receiving pilocarpine had a statistically significant improvement in their salivary flow (P < 0·001), lacrimal flow (P < 0·001) and their subjective global assessment (P < 0·001), compared with patients who received artificial saliva. The most common side-effects were sialorrhoea and nausea. CONCLUSIONS:
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Authors | M Cifuentes, P Del Barrio-Díaz, C Vera-Kellet |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 179
Issue 5
Pg. 1056-1061
(11 2018)
ISSN: 1365-2133 [Electronic] England |
PMID | 29432648
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2018 British Association of Dermatologists. |
Chemical References |
- Muscarinic Agonists
- Saliva, Artificial
- Pilocarpine
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Topics |
- Administration, Oral
- Adult
- Aged
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Muscarinic Agonists
(administration & dosage)
- Nausea
(chemically induced, epidemiology)
- Pilocarpine
(administration & dosage, adverse effects)
- Saliva, Artificial
(administration & dosage, adverse effects)
- Sialorrhea
(chemically induced, epidemiology)
- Sjogren's Syndrome
(complications, drug therapy)
- Treatment Outcome
- Xerophthalmia
(diagnosis, drug therapy, etiology)
- Xerostomia
(diagnosis, drug therapy, etiology)
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