Abstract | BACKGROUND: Postoperative pancreatic fistula (POPF) is more likely to occur in a soft pancreas compared to a hard pancreas in which fibrosis has progressed. There is almost no leakage at the anastomosis site or cut surface of a hard pancreas. The aim of this study was to induce localized fibrosis at the cut surface of the pancreas in a rat model. METHODS: Thirty-six rats were divided into three groups (group S: normal saline group; group E: ethanol group; and group O: octreotide group). Each rat was directly injected with a particular compound at the duodenal lobe of the pancreatic parenchyma. Each group was divided into three subgroups according to the time of post-injection sacrifice (1, 2, or 4 weeks). The hardness, suture holding capacity (SHC), and histological fibrosis grade of each pancreas were measured. RESULTS: The hardness, SHC, and fibrosis grade of groups E and O were increased at week 1, with greater increases in group E (all P < 0.001). In a subgroup comparison, the hardness, SHC, and fibrosis grade of group E tended to decrease gradually over time, with no regular pattern evident in group O. A comparison between the injected site (duodenal lobe) and non-injected site (splenic lobe) of the pancreas revealed increases in the three parameters of group E only in the duodenal lobe, with increases in group O at both the duodenal and splenic lobes. CONCLUSIONS:
|
Authors | Soo Ho Lee, Tae Ho Hong |
Journal | Hepatobiliary & pancreatic diseases international : HBPD INT
(Hepatobiliary Pancreat Dis Int)
Vol. 17
Issue 1
Pg. 81-85
(Feb 2018)
ISSN: 1499-3872 [Print] Singapore |
PMID | 29428110
(Publication Type: Journal Article)
|
Copyright | Copyright © 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved. |
Chemical References |
|
Topics |
- Animals
- Ethanol
(administration & dosage)
- Fibrosis
- Male
- Models, Animal
- Octreotide
(administration & dosage)
- Pancreas
(drug effects, pathology, surgery)
- Pancreatectomy
(adverse effects)
- Pancreatic Fistula
(etiology, pathology, prevention & control)
- Rats, Sprague-Dawley
- Time Factors
|