Risk factor analysis of post-ERCP cholangitis: A single-center experience.

Abstract

BACKGROUND:

Endoscopic retrograde cholangiopancreatography (ERCP) may have complications. Our study aimed to investigate the risk factors and prevention of post-ERCP cholangitis.

METHODS:

We retrospectively analyzed 4234 cases undergone ERCP in the Affiliated Drum Tower Hospital of Nanjing University Medical School from January 2008 to December 2013. Patient-related factors and procedure-related factors were analyzed to find the risk factors of post-ERCP cholangitis. The time point of post-ERCP cholangitis was also analyzed. Univariate and multivariate analyses were performed to define the independent risk factors of post-ERCP cholangitis.

RESULTS:

The success rate of ERCP was 96.8% (4099/4234). The overall complication rate was 9.4% (399/4234). Post-ERCP cholangitis occurred in 102 cases (2.4%, 102/4234). The most dangerous time of post-ERCP cholangitis was from 24 h-48 h after ERCP (45.1%, 46/102). Univariate analysis revealed that age, hypertension, diabetes, previous ERCP history, biliary stent insertion, pancreatography, endoscopic sphincterotomy, balloon dilation and hilar obstruction were risk factors of post-ERCP cholangitis (P < 0.05). Multivariate analysis indicated that age, previous ERCP history and hilar obstruction were independent risk factors (P < 0.05). While endoscopic stone extraction was the potential protective factor.

CONCLUSIONS:

Many risk factors are involved in post-ERCP cholangitis. Among them, old age, previous ERCP history and hilar obstruction were independently related to this post-ERCP complication.

• Authors: Min Chen, Lei Wang, Yun Wang, Wei Wei, Yu-Ling Yao, Ting-Sheng Ling, Yong-Hua Shen, Xiao-Ping Zou
• Journal: Hepatobiliary & pancreatic diseases international : HBPD INT (Hepatobiliary Pancreat Dis Int) Vol. 17 Issue 1 Pg. 55-58 (Feb 2018) ISSN: 1499-3872 [Print] Singapore
• PMID: 29428105 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

Topics

• Aged
• Chi-Square Distribution
• China
• Cholangiopancreatography, Endoscopic Retrograde (adverse effects)
• Cholangitis (diagnosis, etiology, prevention & control, therapy)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Retrospective Studies
• Risk Factors
• Time Factors
• Treatment Outcome