From genetics to the clinic: a translational perspective on follicular lymphoma.

Abstract

Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still considered to be incurable. In recent years, whole-exome sequencing studies of large cohorts of patients have greatly improved our knowledge of the FL mutational landscape. Moreover, the prolonged evolution of this disease has enabled some insights regarding the early pre-lymphoma lesions as well as the clonal evolution after treatment, allowing an evolutionary perspective on lymphomagenesis. Deciphering the earliest initiating lesions and identifying the molecular alterations leading to disease progression currently represent important goals; accomplishing these could help identify the most relevant targets for precision therapy.

• Authors: Sarah Huet, Pierre Sujobert, Gilles Salles
• Journal: Nature reviews. Cancer (Nat Rev Cancer) Vol. 18 Issue 4 Pg. 224-239 (04 2018) ISSN: 1474-1768 [Electronic] England
• PMID: 29422597 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Chromatin

Topics

• Antineoplastic Agents (pharmacology)
• Cell Proliferation
• Cell Survival
• Chromatin (genetics, metabolism)
• DNA Methylation
• Epigenesis, Genetic
• Humans
• Immune Evasion
• Lymphoma, Follicular (etiology, genetics, pathology, therapy)
• Molecular Targeted Therapy
• Mutation
• Translational Research, Biomedical