Abstract |
Polymer proanthocyanidin from Rhodiola semenovii named epihalochin was found to exhibit a pronounced antihypoxic effect in different models of hypoxia (hypoxic, cytotoxic and hemic), to relieve the hypoxic isolated heart contracture. Therapeutic doses of epihalochin produced a transient lowering of arterial pressure, decreased to a certain degree heart rate and lengthened the phases of cardiac contractions.
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Authors | A G Kurmukov, M I Aĭzikov, S S Rakhimov |
Journal | Farmakologiia i toksikologiia
(Farmakol Toksikol)
1986 Mar-Apr
Vol. 49
Issue 2
Pg. 45-8
ISSN: 0014-8318 [Print] Russia (Federation) |
Vernacular Title | K farmakologii rastitel'nogo polifenola épigalokhina. |
PMID | 2940112
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthocyanins
- Biopolymers
- Polymers
- epihaloquine
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Topics |
- Animals
- Anthocyanins
(pharmacology, therapeutic use, toxicity)
- Biopolymers
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Female
- Guinea Pigs
- Hemodynamics
(drug effects)
- Hypoxia
(drug therapy)
- In Vitro Techniques
- Lethal Dose 50
- Male
- Mice
- Myocardial Contraction
(drug effects)
- Plants, Medicinal
- Polymers
(pharmacology, therapeutic use, toxicity)
- Rats
- Stress, Psychological
(drug therapy)
- Uzbekistan
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