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[Pharmacology of the plant polyphenol epigalokhin]

AbstractPolymer proanthocyanidin from Rhodiola semenovii named epihalochin was found to exhibit a pronounced antihypoxic effect in different models of hypoxia (hypoxic, cytotoxic and hemic), to relieve the hypoxic isolated heart contracture. Therapeutic doses of epihalochin produced a transient lowering of arterial pressure, decreased to a certain degree heart rate and lengthened the phases of cardiac contractions.
AuthorsA G Kurmukov, M I Aĭzikov, S S Rakhimov
JournalFarmakologiia i toksikologiia (Farmakol Toksikol) 1986 Mar-Apr Vol. 49 Issue 2 Pg. 45-8 ISSN: 0014-8318 [Print] USSR
Vernacular TitleK farmakologii rastitel'nogo polifenola épigalokhina.
PMID2940112 (Publication Type: Comparative Study, English Abstract, In Vitro, Journal Article)
Chemical References
  • Anthocyanins
  • Biopolymers
  • Polymers
  • epihaloquine
Topics
  • Animals
  • Anoxia (drug therapy)
  • Anthocyanins (pharmacology, therapeutic use, toxicity)
  • Biopolymers
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Female
  • Guinea Pigs
  • Hemodynamics (drug effects)
  • Lethal Dose 50
  • Male
  • Mice
  • Myocardial Contraction (drug effects)
  • Plants, Medicinal
  • Polymers (pharmacology, therapeutic use, toxicity)
  • Rats
  • Stress, Psychological (drug therapy)
  • Uzbekistan

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