Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola.

Abstract

From the plant Schefflera arboricola, which has been reported to cause allergic contact dermatitis, we have isolated and determined the elicitor of allergic contact dermatitis as falcarinol, heptadeca-1,9(Z)-diene-4,6-diyne-3-ol. Three polyacetylenes closely related to falcarinol, namely falcarindiol, falcarinone and dehydrofalcarinone were tested simultaneously. Falcarinol, but not falcarindiol, falcarinone and dehydrofalcarinone, elicited allergic contact dermatitis in a 38-year-old female plant-nursery worker.

• Authors: L Hansen, O Hammershøy, P M Boll
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 14 Issue 2 Pg. 91-3 (Feb 1986) ISSN: 0105-1873 [Print] England
• PMID: 2940058 (Publication Type: Journal Article)

Chemical References

• Alkynes
• Diynes
• Fatty Alcohols
• falcarinol

Topics

• Adult
• Alkynes
• Dermatitis, Contact (etiology)
• Dermatitis, Occupational (chemically induced)
• Diynes
• Fatty Alcohols (adverse effects)
• Female
• Humans
• Patch Tests