Nitroprusside and ketanserin in the treatment of postoperative hypertension following coronary artery bypass grafting: a haemodynamic and ventilatory comparison.

Abstract

Postoperative hypertension following coronary artery bypass grafting is usually treated with vasodilating agents like nitroprusside. In recent studies ketanserin, a 5-hydroxytryptamine type 2 antagonist, appeared to be effective in the treatment of this clinical syndrome. In 20 patients, divided into two comparable groups, nitroprusside and ketanserin were compared with respect to their haemodynamic and ventilatory profiles. The study showed that both agents were equally effective in decreasing the raised systolic blood pressure, but that ketanserin was more advantageous with respect to the absence of reflex tachycardia and the unchanged shunt fraction.

• Authors: P J van der Starre, J E Harinck-de Weerd, R S Reneman
• Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 4 Issue 1 Pg. S107-10 (Apr 1986) ISSN: 0952-1178 [Print] England
• PMID: 2939209 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ferricyanides
• Piperidines
• Nitroprusside
• Ketanserin

Topics

• Blood Pressure
• Coronary Artery Bypass
• Female
• Ferricyanides (therapeutic use)
• Heart Rate
• Humans
• Hypertension (drug therapy, etiology)
• Ketanserin
• Male
• Middle Aged
• Nitroprusside (therapeutic use)
• Piperidines (therapeutic use)
• Postoperative Complications (drug therapy)
• Pulmonary Artery
• Vascular Resistance