Abstract | PURPOSE OF REVIEW: To review publications relating to apolipoprotein L1 (APOL1) renal risk variants published 2017. RECENT FINDINGS: SUMMARY: Our understanding of the role of APOL1 genetic variants and the mechanisms for renal toxicity continues to deepen. It is not yet clear which pathways are most relevant to human disease, and so, the most relevant drug targets remain to be defined.
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Authors | Jeffrey B Kopp, Hila Roshanravan, Koji Okamoto |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 27
Issue 3
Pg. 153-158
(05 2018)
ISSN: 1473-6543 [Electronic] England |
PMID | 29389775
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)
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Chemical References |
- APOL1 protein, human
- Apolipoprotein L1
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Topics |
- Apolipoprotein L1
(chemistry, genetics, metabolism)
- Cardiovascular Diseases
(genetics)
- Gene Dosage
- Genetic Variation
- Humans
- Kidney Diseases
(genetics, metabolism, surgery)
- Kidney Transplantation
- Mitochondria
(physiology)
- Risk Factors
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