Measurement of meperidine and normeperidine in human breast milk by selected ion monitoring.

Abstract

A technique is described for extraction and quantitation of meperidine and normeperidine from breast milk by gas chromatography/mass spectrometry. Both compounds were measured in breast milk from parturients who received the drug for postpartum pain relief. The technique is sensitive to 1 ng ml-1 and standard curves were linear at 1.5-2000 ng ml-1. Levels in breast milk samples were 36.2-314 ng ml-1 and 0-333 ng ml-1 for meperidine and normeperidine, respectively. Preliminary results suggest that postpartum pain medication with meperidine results in considerable levels of both meperidine and its active metabolite, normeperidine, in breast milk.

• Authors: P G Quinn, B R Kuhnert, C J Kaine, C D Syracuse
• Journal: Biomedical & environmental mass spectrometry (Biomed Environ Mass Spectrom) Vol. 13 Issue 3 Pg. 133-5 (Mar 1986) ISSN: 0887-6134 [Print] England
• PMID: 2938653 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Meperidine
• normeperidine

Topics

• Female
• Gas Chromatography-Mass Spectrometry
• Humans
• Meperidine (analogs & derivatives, analysis)
• Milk, Human (analysis)