Irinotecan/IR-820 coloaded nanocomposite as a cooperative nanoplatform for combinational therapy of tumor.

Abstract

AIM:

To enhance synergistic therapeutic effects in breast cancer therapy. Here, we used hollow mesoporous silica nanoparticles as a biocompatible carrier to coload chemotherapy drugs Irinotecan and near-infrared IR-820 dye, which enhanced antitumor efficacy by combining chemotherapy and phototherapy.

METHODS:

The successful synthesis of hollow mesoporous silica nanoparticles/Irinotecan/IR820 (HMII) nanocomplex was confirmed by Fourier  transform infrared spectroscopy and Fluorescence spectra. The photothermal conversion efficiency and antitumor efficiency in murine breast cancer cells (EMT-6) bearing mice were further evaluated.

RESULTS:

The results demonstrated that HMII enhanced the delivery of Irinotecan and IR-820 into EMT-6 cells. HMII generated a high temperature upon a near-infrared laser irradiation (808 nm), and showed higher therapeutic efficacy in EMT-6-bearing mice compared with either HMII without laser or free drug with a laser.

CONCLUSION:

HMII is a desired drug codelivery system to efficiently inhibit the growth of breast cancer.

• Authors: Tingting Li, Xue Shen, Xiaoxue Xie, Zhongyuan Chen, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Yiyao Liu
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 13 Issue 6 Pg. 595-603 (03 01 2018) ISSN: 1748-6963 [Electronic] England
• PMID: 29381122 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• IR 820
• Silicon Dioxide
• Irinotecan
• Doxorubicin
• Indocyanine Green

Topics

• Animals
• Breast Neoplasms (drug therapy, pathology)
• Cell Proliferation (drug effects)
• Doxorubicin (chemistry, pharmacology)
• Drug Delivery Systems
• Female
• Humans
• Indocyanine Green (analogs & derivatives, chemistry, pharmacology)
• Irinotecan (chemistry, pharmacology)
• MCF-7 Cells
• Mice
• Nanocomposites (administration & dosage, chemistry)
• Silicon Dioxide (chemistry, pharmacology)
• Xenograft Model Antitumor Assays