State-dependent effects of beta-endorphin on core temperature in stressed and non-stressed rats.

Abstract

beta-Endorphin, gamma-endorphin, delta-endorphin and morphine injected i.c.v. caused hyperthermia in non-stressed rats; however, the same dose of beta-endorphin and morphine caused hypothermia in stressed animals. These effects of beta-endorphin were antagonized by naloxone. The results suggest that effects of beta-endorphin are different depending on the animal's state and that these effects are mediated via opioid receptors.

• Authors: M Tanaka, A Tsuda, Y Ida, I Ushijima, S Tsujimaru, N Nagasaki
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 39 Issue 3 Pg. 395-7 (Nov 1985) ISSN: 0021-5198 [Print] Japan
• PMID: 2936912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endorphins
• Naloxone
• beta-Endorphin
• Morphine

Topics

• Animals
• Body Temperature (drug effects)
• Endorphins (pharmacology)
• Injections, Intraventricular
• Male
• Morphine (pharmacology)
• Naloxone (pharmacology)
• Rats
• Rats, Inbred Strains
• Stress, Psychological (physiopathology)
• beta-Endorphin