Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat.

We have identified phosphoethanolamine as the pituitary-derived growth-promoting material that specifically stimulates the rat mammary carcinoma cell line 64-24. We have been studying the growth characteristics of the 64-24 cell line, which was isolated from a highly hormone-dependent tumor and which retains in culture many characteristics of the original tumor. Previously, crude bovine pituitary extract was shown to contain a significant amount of growth-stimulating activity for these cells, and a growth factor from this extract was purified to homogeneity. This report describes the identification of the growth factor as phosphoethanolamine. Further, the biological activity of phosphoethanolamine was found to be virtually identical to that of the purified growth factor. A possible role of phosphoethanolamine in the growth of mammary tumor cells as well as of normal mammary epithelial cells and other tissues is discussed.
AuthorsT Kano-Sueoka, D M Cohen, Z Yamaizumi, S Nishimura, M Mori, H Fujiki
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 76 Issue 11 Pg. 5741-4 (Nov 1979) ISSN: 0027-8424 [Print] UNITED STATES
PMID293677 (Publication Type: Journal Article)
Chemical References
  • Ethanolamines
  • Growth Substances
  • Mitogens
  • Phosphates
  • Animals
  • Cell Division (drug effects)
  • Ethanolamines (analysis, pharmacology)
  • Female
  • Growth Substances (isolation & purification)
  • Mammary Neoplasms, Experimental (pathology)
  • Mitogens (isolation & purification)
  • Phosphates
  • Pituitary Gland (analysis)
  • Rats

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