Thymoxamine: a miotic for intraocular use.

Abstract

Thymoxamine hydrochloride can be used intraocularly to reverse phenylephrine or epinephrine mydriasis during intraocular surgery (0.2-0.5 ml of 0.01% or 0.02% solutions proved to be effective). No endothelial damage was found up to a dose of 1 ml of 0.02% thymoxamine in animal experiments using a physiologically buffered solution. Since stability is low in the buffered state, the final concentration has to be prepared at the time of surgery using a 0.5% solution and a phosphate buffer. Intracameral thymoxamine is a potent miotic during operations and can be helpful in extracapsular cataract surgery, keratoplasty, and repair of perforating injuries.

• Authors: F Grehn, T Fleig, E Schwarzmüller
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 224 Issue 2 Pg. 174-8 ( 1986) ISSN: 0721-832X [Print] Germany
• PMID: 2936652 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Miotics
• Moxisylyte

Topics

• Animals
• Cats
• Drug Evaluation
• Drug Evaluation, Preclinical
• Eye Diseases (drug therapy, surgery)
• Humans
• Intraoperative Period
• Miotics (therapeutic use)
• Moxisylyte (therapeutic use)