Dissociation of thrombin generation and platelet secretion in diabetes mellitus.

To determine the relationship between thrombin generation and platelet secretion in vivo in diabetes mellitus, we measured simultaneous plasma beta-thromboglobulin (BTG) and fibrinopeptide A (FPA) in 40 insulin-dependent patients without renal disease, and 20 control subjects of similar age. Log mean plasma BTG and FPA were higher in diabetic patients (32.1 vs 23.7 ng/ml, and 2.83 vs 1.49 ng/ml, p less than 0.001 and less than 0.005, respectively). Neither was correlated with plasma glucose or hemoglobin AI. Plasma BTG and FPA were moderately intercorrelated in control subjects (r = +0.36, p = 0.03), but not in diabetic patients (r = +0.09, p = NS). Thus, in diabetes mellitus, thrombin generation as a contributing mechanism to platelet secretion is probably overshadowed by thrombin-independent mechanisms.
AuthorsM H Rosove, J A Berliner, S S Harwig, H J Frank
JournalDiabetes research (Edinburgh, Scotland) (Diabetes Res) Vol. 2 Issue 4 Pg. 171-3 (Jul 1985) ISSN: 0265-5985 [Print] SCOTLAND
PMID2935351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • beta-Thromboglobulin
  • Fibrinopeptide A
  • Thrombin
  • Adult
  • Age Factors
  • Aged
  • Blood Platelets (secretion)
  • Diabetes Mellitus, Type 1 (blood)
  • Female
  • Fibrinopeptide A (analysis)
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Thrombin (biosynthesis)
  • beta-Thromboglobulin (analysis)

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