Abstract |
After precipitation of the glycoproteins from gastric tumor tissues by caprylic acid, immunochemical methods were applied to the research of specific gastric tumor antigens; this precipitation process by caprylic acid was less aggressive than the use of urea or proteases. The purification of a fraction associated with tumor tissue has been carried out by affinity chromatography with a specific antiserum immobilized on Sepharose. The obtained fraction contains 4 proteic antigens. One of them is common with all the gastric extracts. Neither CEA, nor alpha-foetoprotein has been detected in this fraction. The corresponding antiserum seems to show a tumor specificity, whereas tissue specificity has to be demonstrated.
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Authors | N Remy-Heintz, J P Bali |
Journal | Comptes rendus des seances de la Societe de biologie et de ses filiales
(C R Seances Soc Biol Fil)
Vol. 179
Issue 3
Pg. 389-96
( 1985)
ISSN: 0037-9026 [Print] France |
Vernacular Title | Mise en évidence d'antigènes glycoprotéiques associés aux tumeurs de l'estomac. |
PMID | 2935234
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Glycoproteins
- Immune Sera
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Topics |
- Antigens, Neoplasm
(analysis)
- Electrophoresis, Polyacrylamide Gel
- Glycoproteins
(analysis)
- Humans
- Immune Sera
- Immunodiffusion
- Molecular Weight
- Stomach Neoplasms
(immunology)
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