Magnetoelectric nanoparticles for delivery of antitumor peptides into glioblastoma cells by magnetic fields.

Abstract

AIM:

We studied externally controlled anticancer effects of binding tumor growth inhibiting synthetic peptides to magnetoelectric nanoparticles (MENs) on treatment of glioblastomas.

METHODS:

Hydrothermally synthesized 30-nm MENs had the core-shell composition of CoFe2O4@BaTiO3. Molecules of growth hormone-releasing hormone antagonist of the MIA class (MIA690) were chemically bound to MENs. In vitro experiments utilized human glioblastoma cells (U-87MG) and human brain microvascular endothelial cells.

RESULTS:

The studies demonstrated externally controlled high-efficacy binding of MIA690 to MENs, targeted specificity to glioblastoma cells and on-demand release of the peptide by application of d.c. and a.c. magnetic fields, respectively.

CONCLUSION:

The results support the use of MENs as an effective drug delivery carrier for growth hormone-releasing hormone antagonists in the treatment of human glioblastomas.

• Authors: Tiffanie S Stewart, Abhignyan Nagesetti, Rakesh Guduru, Ping Liang, Emmanuel Stimphil, Ali Hadjikhani, Luis Salgueiro, Jeffrey Horstmyer, Renzhi Cai, Andrew Schally, Sakhrat Khizroev
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 13 Issue 4 Pg. 423-438 (02 2018) ISSN: 1748-6963 [Electronic] England
• PMID: 29345190 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• Barium Compounds
• Drug Carriers
• Ferric Compounds
• Hormone Antagonists
• Magnetite Nanoparticles
• Peptides
• cobalt ferrite
• barium titanate(IV)
• Cobalt
• Growth Hormone
• Titanium

Topics

• Antineoplastic Agents (administration & dosage, chemistry)
• Barium Compounds (chemistry)
• Brain (blood supply)
• Brain Neoplasms (drug therapy)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Cobalt (chemistry)
• Drug Carriers (chemistry)
• Drug Liberation
• Endothelial Cells (cytology, drug effects)
• Ferric Compounds (chemistry)
• Glioblastoma (drug therapy)
• Growth Hormone (antagonists & inhibitors, metabolism)
• Hormone Antagonists (therapeutic use)
• Humans
• Magnetic Fields
• Magnetite Nanoparticles (chemistry)
• Microvessels (cytology)
• Nanospheres (chemistry)
• Particle Size
• Peptides (administration & dosage, chemistry)
• Titanium (chemistry)