HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pilot study of intra-arterial floxuridine, mitomycin and doxorubicin in combination with degradable starch microspheres to treat primary and metastatic tumors of the liver.

Abstract
Concurrent administration of degradable starch microspheres and cytostatic agents into the hepatic artery results in decreased systemic exposure and increased hepatic exposure to drug compared to intra-arterial administration of drug alone. Degradable starch microspheres 210 mg/m2 mixed with floxuridine 500 mg/m2, doxorubicin 40 gm/m2, and mitomycin 10 mg/m2 were administered through hepatic artery catheters to eleven patients with primary or metastatic cancer of the liver. Toxicity was acceptable and consisted of severe myelosuppression (5%), duodenal/gastric ulceration (9%), mild to moderate nausea and vomiting (17%) and alopecia (86%). There were no responses among the eleven patients; 7 of 7 patients with colo-rectal carcinoma had stable disease while on study. Minimal activity was observed in 7 patients with colo-rectal carcinoma. The use of degradable starch microspheres offers a new approach to the regional treatment of cancer and warrants further study.
AuthorsC E Pfeifle, S B Howell, J J Bookstein
JournalCancer drug delivery (Cancer Drug Deliv) Vol. 2 Issue 4 Pg. 305-11 ( 1985) ISSN: 0732-9482 [Print] United States
PMID2933138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Mitomycins
  • Floxuridine
  • Doxorubicin
  • Starch
Topics
  • Adult
  • Aged
  • Doxorubicin (administration & dosage, therapeutic use)
  • Female
  • Floxuridine (administration & dosage, therapeutic use)
  • Humans
  • Injections, Intra-Arterial
  • Liver Neoplasms (drug therapy, secondary)
  • Male
  • Microspheres
  • Middle Aged
  • Mitomycins (administration & dosage, therapeutic use)
  • Starch

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: