Abstract | INTRODUCTION: AREAS COVERED: CD37 seems to be the perfect therapeutic target in patients with NHL. The CD37 antigen is abundantly expressed in B-cells, but is absent on normal stem cells and plasma cells. It is hoped that anti-CD37 monoclonal antibodies will increase the efficacy and reduce toxicity in patients with both newly diagnosed and relapsed and refractory disease. Recent clinical trials have shown promising outcomes for these agents, administered both as monotherapy and in combination with standard chemotherapeutics. EXPERT OPINION: The development of new therapeutic options might help to avoid cytotoxic chemotherapy entirely in some clinical settings. This article presents the latest state of the art on the new treatment strategies in NHL patients. It also discusses recently approved agents and available clinical trial data.
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Authors | Magdalena Witkowska, Piotr Smolewski, Tadeusz Robak |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 27
Issue 2
Pg. 171-177
(02 2018)
ISSN: 1744-7658 [Electronic] England |
PMID | 29323537
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, Neoplasm
- CD37 protein, human
- Tetraspanins
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Topics |
- Antibodies, Monoclonal
(administration & dosage, pharmacology)
- Antigens, Neoplasm
(immunology)
- Humans
- Immunotherapy
(methods)
- Lymphoma, B-Cell
(immunology, therapy)
- Molecular Targeted Therapy
- Tetraspanins
(immunology)
- Therapies, Investigational
(methods)
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