Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice.

Abstract

A series of 15 halogenated hydrocarbons of industrial and environmental importance were tested for carcinogenicity by chronic administration by one or more routes in Ha:ICR Swiss mice. Not all compounds were tested by the four routes of administration used. Allyl chloride, 1,2-dibromo-3-chloropropane, and vinylidene chloride were active as skin tumor initiators in the two-stage carcinogenesis assays; phorbol myristate acetate was used as a promoter. 1,2-Dibromoethane was the only compound that induced a significant incidence (p less than 0.05) of skin papillomas, skin carcinomas, and lung tumors by repeated skin application. 1,2-Dichloroethane, 1,1,2,2-tetrabromoethane, and 1,2-dibromo-3-chloropropane induced lung and/or stomach tumors by repeated skin application. Two compounds showed sarcomagenic activity by sc injection; they were cis-1,3-dichloropropene and 2-chloropropanal. By intragastric intubation, 1-chloropropene and 2-chloropropanal induced significant numbers of stomach tumors. Vehicle, no-treatment, and positive control groups were included in these tests. The following compounds were also tested by one or more of the four routes but were inactive by the criteria used; i.e., they showed P = 0.05 or greater than 0.05: trichloroethylene, tetrachloroethylene, hexachlorobutadiene, chloroacetaldehyde, 1-chloropropene oxide (cis and trans), and trichloroethylene oxide.

• Authors: B L Van Duuren, B M Goldschmidt, G Loewengart, A C Smith, S Melchionne, I Seldman, D Roth
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 63 Issue 6 Pg. 1433-9 (Dec 1979) ISSN: 0027-8874 [Print] United States
• PMID: 292813 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens, Environmental
• Hydrocarbons, Halogenated
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Carcinogens, Environmental
• Cocarcinogenesis
• Drug Evaluation, Preclinical
• Female
• Hydrocarbons, Halogenated (toxicity)
• Lung Neoplasms (chemically induced)
• Male
• Mice
• Neoplasms, Experimental (chemically induced)
• Papilloma (chemically induced)
• Sarcoma, Experimental (chemically induced)
• Skin Neoplasms (chemically induced)
• Stomach Neoplasms (chemically induced)
• Structure-Activity Relationship
• Tetradecanoylphorbol Acetate