Topical 1% propranolol ointment with occlusion in treatment of pyogenic granulomas: An open-label study in 22 children.

Abstract

BACKGROUND:

Pyogenic granuloma (PG) is a common, acquired, benign vascular neoplasm of the skin and mucous membranes. It occurs most often in children and adolescents. First-line treatment options for PG are based on destructive approaches. Pain, permanent scarring, and pigmentation are potential complications of these therapies.

METHODS:

This single-arm, open-label, prospective study evaluated the efficacy of topical propranolol for treatment of PGs in children. All patients clinically diagnosed with cutaneous PG consecutively at the Dermatology Pediatric Outpatient Service of the University of Bologna from January 2010 to December 2010 received a compounded formulation of propranolol ointment 1%.

RESULTS:

We found propranolol ointment to be effective in consecutive patients; 59.0% completely regressed in a mean of 66 days, 18.2% remained stable, and 22.7% did not respond. No side effects (eg, skin irritation, allergy, bleeding) were observed.

CONCLUSION:

Topical propranolol ointment 1% with occlusion appears to be an effective treatment for PGs in children. Early treatment was associated with a more favorable outcome.

• Authors: Iria Neri, Carlotta Baraldi, Riccardo Balestri, Bianca Maria Piraccini, Annalisa Patrizi
• Journal: Pediatric dermatology (Pediatr Dermatol) Vol. 35 Issue 1 Pg. 117-120 (Jan 2018) ISSN: 1525-1470 [Electronic] United States
• PMID: 29266656 (Publication Type: Journal Article)
• Copyright: © 2017 Wiley Periodicals, Inc.

Chemical References

• Vasodilator Agents
• Propranolol

Topics

• Administration, Cutaneous
• Child
• Child, Preschool
• Cicatrix
• Female
• Granuloma, Pyogenic (drug therapy)
• Humans
• Infant
• Male
• Occlusive Dressings (adverse effects)
• Propranolol (administration & dosage)
• Prospective Studies
• Skin (pathology)
• Treatment Outcome
• Vasodilator Agents (administration & dosage)