[A retrospective analysis of functional and oncologic outcomes following surgical treatment of patients with pT1/pT2 renal cell carcinoma at a tertiary referral centre].

Abstract

INTRODUCTION:

In patients with localised renal cell carcinoma, the only curative treatment option is surgical tumour excision. The aim of this study was to evaluate peri- and postoperative outcomes as well as oncologic and functional long-term results following surgical treatment of patients with renal cell carcinoma (pT1/pT2) at a tertiary referral centre.

PATIENTS AND METHODS:

This retrospective study included a total of 758 patients with localised renal cell carcinoma (pT1 /pT2), who underwent radical (RN) or partial (PN) nephrectomy between 01/2008 and 10/2014. Pre-, peri- and postoperative parameters were recorded. Oncologic and functional long-term data were retrieved through questionnaires and structured telephone interviews.

RESULTS:

Laparoscopic RN or PN resulted in less blood loss and lower peri- and postoperative complication rates compared to open procedures. Regarding short- and long-term renal function, a higher increase in serum creatinine levels was detected after RN. No difference was noted in health status and quality of life. Median follow-up was 36 months. A total of 10.4 % of patients died during follow-up. 4.7 % and 8.4 % developed a relapse or metastatic disease. No difference was found between laparoscopic and open RN/PNs in terms of oncologic long-term results.

DISCUSSION:

In conclusion, all surgical techniques evaluated in this study provided good oncologic and functional short-/long-term outcomes.

• Authors: Bernhard Ralla, Stephanie Buhl, Irena Goranova, Andreas Maxeiner, Frank Friedersdorff, Ahmed Magheli, Stefan Hinz, T Florian Fuller, Kurt Miller, Jonas Busch
• Journal: Aktuelle Urologie (Aktuelle Urol) Vol. 51 Issue 3 Pg. 290-298 (06 2020) ISSN: 1438-8820 [Electronic] Germany
• Vernacular Title: Peri- und postoperatives Ergebnis nach Nierentumorchirurgie bei pT1/pT2 Nierenzellkarzinom – eine retrospektive Zentrumsanalyse der funktionellen und onkologischen Ergebnisse.
• PMID: 29258130 (Publication Type: Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Carcinoma, Renal Cell (surgery)
• Humans
• Kidney Neoplasms (surgery)
• Neoplasm Recurrence, Local
• Nephrectomy
• Quality of Life
• Retrospective Studies
• Tertiary Care Centers
• Treatment Outcome