Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Abstract

The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58-1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20-0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26-0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self-reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample.

• Authors: Tomotaka Ugai, Linda E Kelemen, Mika Mizuno, Jue-Sheng Ong, Penelope M Webb, Georgia Chenevix-Trench, Australian Ovarian Cancer Study Group, Kristine G Wicklund, Jennifer Anne Doherty, Mary Anne Rossing, Pamela J Thompson, Lynne R Wilkens, Michael E Carney, Marc T Goodman, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Hui Cai, Xiao-Ou Shu, Yu-Tang Gao, Yong-Bing Xiang, David Van Den Berg, Malcom C Pike, Anna H Wu, Celeste Leigh Pearce, Keitaro Matsuo, Ovarian Cancer Association Consortium
• Journal: Cancer science (Cancer Sci) Vol. 109 Issue 2 Pg. 435-445 (Feb 2018) ISSN: 1349-7006 [Electronic] England
• PMID: 29247577 (Publication Type: Journal Article)
• Copyright: © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• ALDH2 protein, human
• Aldehyde Dehydrogenase, Mitochondrial

Topics

• Adenocarcinoma, Mucinous (genetics)
• Alcohol Drinking (genetics)
• Aldehyde Dehydrogenase, Mitochondrial (genetics)
• Asian People (genetics)
• Cohort Studies
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Logistic Models
• Odds Ratio
• Ovarian Neoplasms (genetics)
• Polymorphism, Single Nucleotide