Quantitation of human thymus/leukemia-associated antigen by radioimmunoassay in different forms of leukemia.

Abstract

Using a radioimmunoassay, increased levels of a human thymus/leukemia-associated antigen (HThy-L) have been detected in leukemic cells and plasma from most patients with E-rosette-positive acute lymphoblastic leukemia (ALL) and a number of patients with E-rosette-negative ALL, acute myeloblastic leukemia (AML), acute monomyelocytic leukemia (AMML), and acute undifferentiated leukemia (AVL). Low levels of HThy-L have been demonstrated in white cells from patients with chronic myelocytic leukemia (stable phase) and in mononuclear cells from patients with chronic lymphatic leukemia. The relationship between HThy-L and differentiation of hematopoietic cells is discussed.

• Authors: B E Chechik, J Jason, A Shore, M Baker, H M Dosch, E W Gelfand
• Journal: Blood (Blood) Vol. 54 Issue 6 Pg. 1400-6 (Dec 1979) ISSN: 0006-4971 [Print] United States
• PMID: 292458 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Antigens, Neoplasm
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Leukemia (immunology)
• Leukemia, Lymphoid (immunology)
• Leukemia, Myeloid (immunology)
• Leukemia, Myeloid, Acute (immunology)
• Male
• Middle Aged
• Radioimmunoassay
• Rosette Formation
• Thymus Gland (immunology)