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Retinol and retinyl esters in patients with alcoholic liver disease.

Abstract
Liver retinoid levels and the retinyl esters were examined in liver biopsy specimens from 70 patients with alcoholic and nonalcoholic liver diseases. There was a wide variation in the liver retinoid levels. The liver retinoid level was statistically significantly lower in 15 patients with alcoholic liver disease and a depressed Normotest (NT) value of less than 65% compared with patients with alcoholic liver disease and a normal NT value of greater than 65% (P less than 0.01). The mean serum retinol level in patients with alcoholic cirrhosis was 0.68 +/- 0.38 mumol/l compared with 1.99 +/- 1.14 mumol/l in patients with alcoholic fatty liver (P less than 0.03). The relative amount of retinyl oleate was increased in the alcoholic fatty liver compared with the nonalcoholic fatty liver (P less than 0.001).
AuthorsH Bell, A Nilsson, K R Norum, L B Pedersen, N Raknerud, M Rasmussen
JournalJournal of hepatology (J Hepatol) Vol. 8 Issue 1 Pg. 26-31 (Jan 1989) ISSN: 0168-8278 [Print] Netherlands
PMID2921501 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diterpenes
  • Retinoids
  • Retinol-Binding Proteins
  • Retinyl Esters
  • Vitamin A
  • retinol palmitate
  • Ethanol
  • retinol oleate
Topics
  • Adult
  • Aged
  • Diterpenes
  • Ethanol (pharmacology)
  • Fatty Liver (metabolism)
  • Fatty Liver, Alcoholic (metabolism)
  • Female
  • Humans
  • Liver (metabolism)
  • Liver Diseases (blood, enzymology, metabolism)
  • Liver Diseases, Alcoholic (blood, enzymology, metabolism)
  • Male
  • Middle Aged
  • Retinoids (metabolism)
  • Retinol-Binding Proteins (blood)
  • Retinyl Esters
  • Vitamin A (analogs & derivatives, metabolism)

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