Tumor imaging of Dalton's lymphoma using antibody-desferal-Ga-67 complex.

Abstract

Using desferal, a bifunctional chelating agent, Ga-67 was conjugated to the antibody, anti DLAA, specific for a 80 KD antigen associated with Dalton's lymphoma (DLAA) and was used for imaging of murine lymphomas induced by an 'air-pouch' technique. Scintiscan studies were carried out at 24 hr, 48 hr, 72 hr, after i.v. administration of Ga-67-anti DLAA-DF complex and compared with scintigrams obtained after administration of free Ga-67 citrate and suspension of Ga-67, DF, anti DLAA to different batches of tumor bearing mice. The study was also carried out using mouse IgG, a non-specific antibody, instead of anti DLAA. The results were compared with biodistribution studies. Scintigrams demonstrated that with anti DLAA there was maximum uptake of Ga-67 by the tumor providing the best images.

• Authors: M Udayachander, A Meenakshi, M Sivanandham
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 16 Issue 3 Pg. 731-6 (Mar 1989) ISSN: 0360-3016 [Print] United States
• PMID: 2921171 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Neoplasm
• Antigens, Neoplasm
• Citrates
• Citric Acid
• Deferoxamine

Topics

• Animals
• Antibodies, Neoplasm (immunology)
• Antigens, Neoplasm (immunology)
• Citrates
• Citric Acid
• Deferoxamine
• Isotope Labeling
• Lymphoma (diagnostic imaging, immunology)
• Mice
• Radionuclide Imaging