Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma.

Abstract

PURPOSE:

To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG).

DESIGN:

Open-label, non-comparative, observational case study with non-probability purposive sampling.

METHODS:

A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0.005%). IOP was subsequently measured at 4 weeks and 12 weeks, respectively. The primary end point was reduction in IOP at 12 weeks after the initiation of treatment.

RESULTS:

A total of 48 patients (94 eyes) were recruited from glaucoma clinic. The average IOP of our patients at baseline was 28.6 ± 8.1 mmHg, decreasing to 21.3 ± 10.6 mmHg at 4 weeks, indicating a drop of 19.1% (P < 0.001). IOP further decreased to 20.3 ± 8.7 mmHg after 3 months of treatment indicating a decrease of 23.3% (P < 0.001). A decrease in IOP occurred in 51 eyes (71.8%) at 4 weeks after treatment, improving to 54 eyes (76%) at 3-month follow-up. Twenty eyes (28.1%) did not show any change in IOP at 4 weeks. However, after 3-month follow-up only 17 eyes (23.9%) did not reveal any change in IOP.

CONCLUSION:

Our results showed a decrease in IOP of 19.1% after 4 weeks, increasing to 23.3% at 12 weeks in cohort of 37 patients (72 eyes) treated with locally produced Latanoprost (Vislat 0.005%).

• Authors: Pir Salim Mahar, Nadeem H Butt, Syed Imtiaz Ali
• Journal: International ophthalmology (Int Ophthalmol) Vol. 38 Issue 6 Pg. 2593-2597 (Dec 2018) ISSN: 1573-2630 [Electronic] Netherlands
• PMID: 29209880 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Antihypertensive Agents
• Latanoprost

Topics

• Adolescent
• Adult
• Aged
• Antihypertensive Agents (therapeutic use)
• Female
• Glaucoma, Open-Angle (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (physiology)
• Latanoprost (therapeutic use)
• Male
• Middle Aged
• Ocular Hypertension (drug therapy, physiopathology)
• Tonometry, Ocular
• Young Adult