Transient neonatal hyperglycinemia.

Abstract

Two patients with neonatal seizures and subsequent normal neurological development were found to have nonketotic hyperglycinemia. In both patients, hyperglycinemia resolved at 6 weeks of age. After cerebrospinal fluid glycine levels were normalized, the seizures stopped completely in one child and were markedly improved in the other. The possible mechanisms for the hyperglycinemia are discussed.

• Authors: R Schiffmann, E M Kaye, J K Willis 3rd, D Africk, M Ampola
• Journal: Annals of neurology (Ann Neurol) Vol. 25 Issue 2 Pg. 201-3 (Feb 1989) ISSN: 0364-5134 [Print] United States
• PMID: 2919871 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Glucose
• Glycine

Topics

• Amino Acid Metabolism, Inborn Errors (diagnosis, genetics)
• Blood Glucose (metabolism)
• Female
• Follow-Up Studies
• Genes, Recessive
• Glycine (blood)
• Humans
• Infant, Newborn
• Male
• Spasms, Infantile (genetics)