HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity.

Abstract
The mechanism(s) of adverse reactions to sulfites remains unclear. To determine whether mast cell degranulation is involved in sulfite sensitivity, we performed single-blind, placebo-controlled oral aqueous challenges with potassium metabisulfite in 13 patients with histories suggestive of sulfite sensitivity. Ten patients were also skin tested with potassium metabisulfite at 10 mg/mL and all had negative reactions. Serum samples were obtained from all the patients before the challenge and for 180 minutes after the challenge. The samples were tested for the presence of neutrophil chemotactic factor of anaphylaxis, using both a 51chromium microchamber chemotaxis assay and a leukocyte polarization technique. Six of 13 patients had positive challenges as defined by a fall equal to or greater than 20% in their forced expiratory volume in one second. No significant increase in neutrophil chemotactic factor activity was detected in the postchallenge serum samples from patients who experienced positive or negative challenges. We conclude that sensitivity to aqueous metabisulfite is not associated with mast cell degranulation in metabisulfite skin test-negative patients.
AuthorsJ D Sprenger, L C Altman, S G Marshall, W E Pierson, J Q Koenig
JournalAnnals of allergy (Ann Allergy) Vol. 62 Issue 2 Pg. 117-21 (Feb 1989) ISSN: 0003-4738 [Print] United States
PMID2919798 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Chemotactic Factors
  • Sulfites
  • metabisulfite
Topics
  • Adult
  • Anaphylaxis (chemically induced, immunology)
  • Asthma (chemically induced)
  • Bronchospirometry
  • Chemotactic Factors (immunology)
  • Drug Hypersensitivity (etiology, immunology)
  • Female
  • Humans
  • Male
  • Mast Cells (immunology)
  • Middle Aged
  • Neutrophils (immunology)
  • Sulfites (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: