[Effect of estradiol dipropionate on the development of uterine sarcoma induced by 1,2-dimethylhydrazine in mice].

Abstract

The study was concerned with the influence of single dose of estradiol dipropionate on its promoting effect on 1,2-dimethylhydrazine-induced tumors in female CBA/CaLac mice. Estradiol dipropionate given within 19 weeks did not affect carcinogenesis whereas 39-week treatment stimulated uterine sarcoma development irrespective of single dose and schedule of administration.

• Authors: O V Morozova, L S Trukhanova, Iu D Parfenov, N N Klepikov, V S Turusov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 35 Issue 1 Pg. 52-7 ( 1989) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Vliianie éstradiola dipropionata na razvitie sarkom matki, vyzyvaemykh 1,2-dimetilgidrazinom u mysheĭ.
• PMID: 2919505 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Carcinogens
• Dimethylhydrazines
• Methylhydrazines
• Estradiol
• 1,2-Dimethylhydrazine
• estradiol dipropionate

Topics

• 1,2-Dimethylhydrazine
• Alleles
• Animals
• Carcinogens
• Cocarcinogenesis
• Dimethylhydrazines (toxicity)
• Estradiol (analogs & derivatives, toxicity)
• Female
• Genotype
• Methylhydrazines (toxicity)
• Mice
• Mice, Inbred CBA (genetics)
• Sarcoma, Experimental (chemically induced, epidemiology)
• Time Factors
• Uterine Neoplasms (chemically induced, epidemiology)